Wide Dissemination of a Carbapenemase Plasmid among Gram-Negative Bacteria: Implications of the Variable Phenotype
نویسندگان
چکیده
منابع مشابه
Wide dissemination of a carbapenemase plasmid among gram-negative bacteria: implications of the variable phenotype.
Broad-spectrum carbapenem antibiotics are the last bastion of empirical therapy for resistant gram-negative bacterial infections, and outbreaks of carbapenem-resistant bacterial infection may be associated with greatly increased mortality in the critically ill (4). Carbapenems (e.g., imipenem, meropenem, ertapenem) are increasingly threatened by dissemination of metallo-lactamases (M Ls), the m...
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The greatest threat to antimicrobial treatment of infections caused by Gram-negative bacteria is the production of carbapenemases. Metallo-beta-lactamases and plasmid-mediated serine carbepenemases like Klebsiella pneumonia carbapenemase are threatening the utility of almost all currently available beta-lactams including carbapenems. Detection of organisms producing carbapenemases can be diffic...
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The emergence of the multiresistance gene cfr in staphylococci is of global concern. In addition to conferring resistance to phenicols, lincosamides, pleuromutilins, streptogramin A antibiotics and selected 16-membered macrolides, the cfr gene also confers resistance to the oxazolidinone linezolid. Linezolid is a last-resort antimicrobial agent for the treatment of serious infections in humans ...
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We determined the sequence and genetic organization of plasmid pIP823, which contains the dfrD gene; dfrD confers high-level trimethoprim resistance to Listeria monocytogenes BM4293 by synthesis of dihydrofolate reductase type S2. pIP823 possessed all the features of the pUB110/pC194 plasmid family, whose members replicate by the rolling-circle mechanism. The rep gene encoded a protein identica...
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ژورنال
عنوان ژورنال: Journal of Clinical Microbiology
سال: 2005
ISSN: 0095-1137,1098-660X
DOI: 10.1128/jcm.43.9.4918-4919.2005